FAQs

A: Yes, NITYR contains the active ingredient nitisinone. NTBC is an abbreviation for nitisinone and the two terms mean the same thing.

A: NITYR is tasteless.

A: Cycle Pharmaceuticals manufactures NITYR in Switzerland.

A: The medication is delivered directly to a location of your choice and comes with a convenient proactive refill program.

A: Yes, with the NITYR Experience, you can try NITYR, compare it to your current nitisinone medication and decide if NITYR is right for you. You can start with the 30-Day Free NITYR Program** with:

• No financial obligation
• No commitment
• No impact on your current nitisinone

The 30-Day Free NITYR Program gives you the opportunity to decide if NITYR is right for you and your family. During the Program, you will receive calls from our NITYR Patient Liaison Support Team, including an initial call to discuss NITYR and explain how to administer the medication. If you have any questions before, during or after the Program, our NITYR Patient Liaison Support are available on 1-800-847-8714. For more information on the 30-Day Free NITYR Program click here.

A: No, NITYR is stable at room temperature between 68°F and 77°F (20°C to 25°C), allowing for excursions between 59°F and 86°F (15°C and 30°C) until its expiry date.

A: NITYR has the same efficacy and safety profile as your current nitisinone (NTBC) treatment.

Adverse reactions
The most common adverse reactions (≥1%) in patients with HT-1 taking nitisinone are elevated tyrosine levels, low platelets (thrombocytopenia) or white cells in the blood (leukopenia), and complaints related to the eyes, including conjunctivitis, corneal opacity, inflammation of the cornea, eye pain and extreme sensitivity to light (photophobia), nosebleed (epistaxis), itching (pruritus), skin inflammation (exfoliative dermatitis), rash (maculopapular rash), dry skin and alopecia.

A: NITYR tablets are very small² (baby aspirin sized) and can be easily swallowed by patients from 3 years old. However, the ability of the patient to swallow the tablet should be established by your HCP (a 30-Day Free Program is available**).

For those unable to swallow a tablet, NITYR can be converted to a suspension that can be administered via an oral syringe. The suspension can be stored at room temperature for up to 24 hours before use. If your child can swallow soft food, NITYR tablets can also be crushed and added to applesauce. Further information and a short video are available here.

A: Generally, children aged 3 years and older can swallow NITYR tablets (baby aspirin sized²). However, check with your healthcare provider before administering NITYR tablets to young children (a 30-Day Free Program is available**).

Children under 3 years old can take NITYR by creating a suspension using an oral syringe (watch video here) or by crushing the tablets and mixing them with applesauce. The suspension can be stored at room temperature for up to 24 hours before use. Our Patient Liaison Support Team can provide training, oral syringes and tablet crushers free of charge and give you tips on how to teach your child to swallow NITYR Tablets. Please call 1-800-847-8714.

A: Yes, we provide the NITYR Patient Support Program for US patients and caregivers. You can call the Patient Support Team and gain advice and support from a specialist pharmacist when you need help or have any questions. The program also includes delivery of your medication to your home and proactive refills. For more information call 1-800-847-8714 or visit here.

A: If you forget a dose, take the next dose as planned. Do not take a double dose to make up for a forgotten dose. Contact your healthcare provider or the NITYR Patient Support Program on 1-800-847-8714 for further advice.

A: Your child should follow a low-protein diet and avoid foods and drinks that contain phenylalanine or tyrosine. You should work with your healthcare provider and consult a metabolic dietitian skilled in helping people manage amino acid disorders for specific dietary instructions. Dietitian consultations are available through the NITYR Patient Nutrition Program^§.

A: No. Tyrosinemia Type 1 is a lifelong condition and it’s important to maintain recommended medication and dietary routines to lower the risk of adverse health outcomes.

A: NITYR Tablets contain nitisinone, which prevents the build-up of toxic substances which cause severe liver and kidney problems in patients with Tyrosinemia Type 1. Patients still need to follow a low-protein diet, restricting the intake of phenylalanine and tyrosine to control tyrosine levels in the body.

A: For NITYR availability in other countries please contact: sales-distribution@cyclepharma.com

A: NITYR (nitisinone) tablets are bioequivalent to Orfadin* (nitisinone) capsules, which means they have the same efficacy, safety and side effects, and may offer patients and their families greater convenience.¹

NITYR is also stable at room temperature between 68°F to 77°F (20°C to 25°C), allowing for excursions between 59°F and 86°F (15°C and 30°C), until its expiry date, freeing you from having to refrigerate the medication.

NITYR tablets are tasteless and very small² (baby aspirin sized) and come in 2 mg, 5 mg and 10 mg tablets. NITYR can also be taken with or without food.

A: NITYR is bioequivalent to Orfadin*, which means that it has the same efficacy, safety and side effects, and may offer you and your family greater convenience.¹

A: Because NITYR (nitisinone) Tablets are bioequivalent to Orfadin* capsules, NITYR has the same efficacy, safety and adverse reactions.¹

A: Our team can make a full benefit investigation to tell you how much NITYR will cost. We also offer $0 Co-pay for eligible patients.^||

Talk to your healthcare provider and ask them to complete a 30-Day Free NITYR Program** enrollment form. The results will help you with the decision.

A: No, patients who move to NITYR are not expected to experience any new adverse reactions. The most common adverse reactions (≥1%) in patients with HT-1 taking nitisinone are elevated tyrosine levels, low platelets (thrombocytopenia) or white cells in the blood (leukopenia), and complaints related to the eyes, including conjunctivitis, corneal opacity, inflammation of the cornea, eye pain and extreme sensitivity to light (photophobia), nosebleed (epistaxis), itching (pruritus), skin inflammation (exfoliative dermatitis), rash (maculopapular rash), dry skin and alopecia. Click here for full adverse events and prescribing information.